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Drug Interactions With Lomustine

Live Vaccinations
In general, live vaccines are not recommended for people undergoing chemotherapy treatment, including lomustine. This is because live vaccines contain live viruses or bacteria. Because lomustine can decrease the body's immune response, you could become infected with the virus or bacteria used to make the vaccine. Also, live vaccines may be less effective in people taking lomustine. Talk to your healthcare provider before getting a vaccination during lomustine treatment.
 
Peginterferon Alfa-2b
Peginterferon alfa-2b may decrease blood levels of lomustine, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take these medicines together.
 
Pimozide
Lomustine could increase blood levels of pimozide, increasing your risk for side effects. In general, these medications are not recommended for use together. However, there may be times when the combination cannot be avoided. Talk to your healthcare provider about this interaction if you take pimozide and lomustine.
 
Sipuleucel-T
Lomustine can make sipuleucel-T less effective. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while lomustine decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before taking these medicines together.
 

Final Thoughts

It is possible that not all drug interactions with lomustine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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