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Drug Interactions With Lomustine

More Detail on Drug Interactions With Lomustine

The following sections explain in detail the potentially negative interactions that can occur when lomustine is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with chemotherapy medicines, including lomustine, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together.
 
Aripiprazole
Lomustine may increase blood levels of aripiprazole, increasing the risk for side effects. Your healthcare provider may need to adjust your dose of aripiprazole if you take these medicines together, although in many cases dose adjustments are not needed.
 
Certain Immunosuppressant Medicines
Taking lomustine in combination with other medicines that suppress the immune system could increase your risk for potentially serious side effects, including low blood cell counts and infections. It is generally recommended that lomustine not be used in combination with some of these medicines, while other combinations can be used with careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking other immunosuppressant drugs.
 
Clozapine
Taking clozapine with lomustine could increase your risk for dangerously low white blood cell counts, which could make you more susceptible to potentially serious infections. Talk to your healthcare provider before taking these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
Echinacea
Echinacea may decrease the effectiveness of lomustine. Do not take echinacea during lomustine treatment without your healthcare provider's approval.
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Lomustine Drug Information

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