Lofibra Drug Interactions (Cont.)

 
Warfarin
Lofibra can increase the anticoagulant effect of warfarin. This means that you are at an increased risk of bleeding if you are taking Lofibra and warfarin together. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments.
 
HMG-CoA Reductase Inhibitors
The use of Lofibra with a statin medication should generally be avoided due to the increased risk for kidney and muscle problems. This combination should only be used if the benefit of further lowering cholesterol levels outweighs the risk.
 
Cyclosporine
Cyclosporine can make it harder for Lofibra to be eliminated from the body. If you are taking both Lofibra and cyclosporine, you may be at increased risk for developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments if this is the case.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to Lofibra in the digestive tract and decrease its absorption into the body. Lofibra should be taken at least one hour before or four to six hours after a bile acid sequestrant has been given to avoid this drug interaction.
 

Lofibra Drug Interactions: A Summary

It is possible that not all Lofibra drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or doctor about any possible drug interactions that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;