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Lofibra and Liver Problems

Side effects and complications may develop with Lofibra, and liver problems, such as increased liver enzymes or fatty deposits, may require close monitoring by your healthcare provider. Symptoms that may indicate liver problems include nausea or vomiting, stomach pain, and passing brown or dark-colored urine. If your doctor suspects a link between Lofibra and liver problems, you may be switched to another cholesterol medication.

Lofibra and Liver Problems: An Overview

As with any medication, there are a number of possible side effects that can occur while taking Lofibra® (fenofibrate), including possible problems with the liver. For people taking Lofibra, liver problems can include an increase in liver enzymes and fatty change in the liver.
 
Increases in liver enzymes occur in up to 13 percent of people taking Lofibra. Fatty deposits in the liver occur in less than 1 percent of people. Given the rarity of fatty deposits, it is difficult to tell whether the side effect is caused by the medication itself or by something else.
 

Lofibra and Liver Problems: High Liver Enzymes

Liver enzymes are usually measured to see if a person has liver damage. They do not measure how well the liver is working. A number of things can increase liver enzymes, including certain medicines (such as antibiotics or certain anti-inflammatory medicines), alcohol, infections (such as mononucleosis or viral hepatitis), obesity, and diabetes.
 
Lofibra is known to increase liver enzyme levels. This increase in liver enzymes, however, except in very rare cases, does not cause any symptoms. Despite this, your doctor will measure your liver enzyme levels prior to you starting Lofibra and then again several months after you start. He or she will also measure your liver enzyme levels if your Lofibra dosage is increased.
 
If your liver enzymes are high, your doctor may continue to test them on a more frequent basis. If they remain high, your doctor may recommend lowering the dose of Lofibra or switching to another cholesterol medication. When Lofibra is stopped, the liver enzymes, in most cases, return to the pre-Lofibra levels.
 
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