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What Is Leuprolide Used For?

Depending on which form of the drug is being used, leuprolide can help treat advanced prostate cancer, endometriosis, and other conditions. In some cases, a healthcare provider may prescribe leuprolide "off-label" for the treatment of uterine or breast cancer. This medication works by decreasing the amount of testosterone (for males) and estrogen (in females) made by the body.

An Overview of Uses for Leuprolide

Leuprolide (Eligard®, Lupron®, Lupron Depot®) is a prescription medication that belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) agonists. This group of medications is also sometimes called luteinizing hormone-releasing hormone (LH-RH) agonists.
 
Leuprolide comes as a daily subcutaneous injection (an injection given just under the skin), a long-acting subcutaneous injection, and an intramuscular injection (an injection given into a muscle). The long-acting subcutaneous injection (Eligard) is only approved to ease the symptoms of advanced prostate cancer. The regular subcutaneous injection (Lupron) is approved to:
 
  • Ease the symptoms of advanced prostate cancer
  • Treat central precocious puberty, a condition in which puberty occurs too soon in children.
     
The long-acting intramuscular injection (Lupron Depot) is approved to:
 
  • Ease the symptoms of advanced prostate cancer
  • Treat central precocious puberty in children
  • Manage symptoms of endometriosis (a condition in which the tissue that normally lines the uterus grows in other areas of the body)
  • Manage anemia before surgery for uterine fibroids (noncancerous tumors of the uterus).
     
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Leuprolide Acetate Drug Information

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