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Leuprolide Side Effects

In clinical studies, hot flashes were reported by up to 84 percent of adults receiving treatment with leuprolide. Other common side effects include headache, general body pain, and reactions at the injection site (such as burning or stinging). If you develop blood in the urine, a migraine headache, chest pain, or any other potential serious problems, contact your healthcare provider right away.

An Introduction to Leuprolide Side Effects

Just like any medicine, leuprolide (Eligard®, Lupron®, Lupron Depot®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with leuprolide. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Leuprolide

Some leuprolide side effects, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Blood in the urine or difficulty urinating
  • Persistent or extreme bone pain
  • Signs of puberty in children after two months of treatment, including menstrual bleeding or spotting in girls
  • Redness, pain, pus, bleeding, or other skin reactions at the injection site that are severe or do not go away
  • Migraine headache or sudden, severe headache
  • Changes in vision, including loss of vision or blurred vision
  • Sudden confusion
  • Sudden numbness or weakness of the face, arm, or leg
  • Chest pain (angina)
  • Fluid retention or swelling
  • Shortness of breath, coughing, or worsening asthma
  • Black, tarry, or bloody stools
  • Vomit that looks like coffee grounds or has bright-red blood in it
  • Feelings of a rapid or forcefully beating heart (palpitations)
  • Sudden dizziness or loss of balance or coordination
  • Mood changes, such as:
  • Low blood pressure (hypotension)
  • Bone fracture
  • Seizure
  • Changes in blood sugar or signs of diabetes, such as:
    • Frequent urination
    • Increased thirst
    • Blurred vision
    • Fatigue
    • Weight loss
    • Tingling or numbness of the hands or feet
  • Signs of an allergic reaction, such as:
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing or difficulty breathing or swallowing.
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Leuprolide Acetate Drug Information

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