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Leuprolide Dosage

Dose of Leuprolide for Endometriosis and Uterine Fibroids

Leuprolide is available in one-month and three-month forms for endometriosis and uterine fibroids as Lupron Depot. The standard dosage will depend on the particular form used, but will usually be one of the following:
  • Leuprolide 3.75 mg once a month
  • Leuprolide 11.25 mg once every three months.
Leuprolide may be given alone or in combination with norethindrone acetate for initial treatment of endometriosis for up to six months. If your symptoms recur after the initial six-month course, your healthcare provider may recommend another six months of treatment.
Norethindrone should be given in addition to leuprolide during the second six-month treatment course. This is because norethindrone helps reduce the risk of bone thinning that occurs when leuprolide is used for long-term treatment.
The recommended length of treatment of leuprolide for uterine fibroids is up to three months. If treatment beyond three months is desired, your healthcare provider will need to check your bone health before additional leuprolide doses are given.

General Information on Using Leuprolide

Some considerations to keep in mind during treatment with leuprolide include the following:
  • This medication comes in the form of a subcutaneous (just under the skin) or intramuscular (into the muscle) injection. It can be given once a day, monthly, or once every three to six months, depending on the particular product used.
  • The injection may be given by your healthcare provider in a healthcare setting or self-administered. If you are giving the injection to yourself (or your child), your healthcare provider should show you exactly how to do it. Make sure to ask questions if you are unsure about any of the steps.
  • The injection site should be changed periodically to protect the skin from too much irritation.
  • Do not use leuprolide if it contains particles or is cloudy or discolored.
  • For this drug to work properly, it must be taken as prescribed. Do not stop using it because you feel better. Stopping treatment too soon may cause your symptoms to return.
  • If you are unsure about anything related to your leuprolide dosage, please talk with your healthcare provider, nurse, or pharmacist.
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