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Leuprolide Dosage

Leuprolide Subcutaneous Injection
The usual initial dose of leuprolide subcutaneous injection for children with central precocious puberty is 50 mcg per kg of body weight once a day (about 22.7 mcg per pound once a day). The dose may be increased by 10 mcg per kg body weight (about 4.5 mcg per pound) daily every one to two months until an amount is found that adequately stops puberty.
 
Leuprolide Intramuscular Injection
The usual initial dosage of leuprolide intramuscular injection for children with central precocious puberty is as follows:
 
  • Children who weigh 25 kg or less (55 pounds or less) are given 7.5 mg every four weeks
  • Children who weigh 25 to 37.5 kg (55 to 82.5 pounds) are given 11.25 mg every four weeks
  • Children who weigh more than 37.5 kg (82.5 pounds) are given 15 mg every four weeks.
     
Your child's healthcare provider will monitor your child's response to treatment after one or two months, and increase the dose if needed. The amount may be increased by 3.75 mg no more often than every four weeks until a dosage is found that adequately stops puberty.
 
Two new once-every-three months strengths of Lupron Depot (pediatric) have been approved. These two strengths (11.25 mg and 30 mg) are given once every 12 weeks. No weight-based dosing guidelines are available for these products.
 
Ongoing Dosage Adjustments
Your child may need periodic dose adjustments to prevent puberty as he or she grows. Your child's healthcare provider will continue to monitor your child's response to leuprolide to determine if an adjustment is needed. It is recommended that leuprolide injection be stopped before age 11 in girls and age 12 in boys to allow for normal sexual maturation.
 
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Leuprolide Acetate Drug Information

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