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Lenalidomide Side Effects

Most people who take lenalidomide will develop some type of side effect during treatment. Some of the most commonly reported reactions to this drug include constipation, itching, and muscle cramps. While reactions tend to be mild and easy to treat, there are some potentially dangerous lenalidomide side effects that can occur. Call your healthcare provider immediately if you develop vision changes, fever, or seizures.

An Introduction to Side Effects of Lenalidomide

Just like any medicine, lenalidomide (Revlimid®) can cause side effects. Although not everyone who uses the drug will have problems, the majority of people will experience some type of lenalidomide side effect during treatment.
If reactions do occur, in most cases, they are mild and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
(This article covers many, but not all, of the possible side effects with lenalidomide. Your healthcare provider can discuss a more complete list with you.)

Serious Lenalidomide Side Effects

Some side effects of lenalidomide are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • A rash, which may be a sign of a potentially life-threatening skin reaction known as Stevens-Johnson syndrome (SJS)
  • Signs of infection, such as:
    • Fever
    • Chills
    • Aches and pains
    • Sore throat
    • Cough
    • Nausea
    • Vomiting
  • Shortness of breath
  • Chest pain
  • Swelling in an arm or leg
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Upper-right abdominal (stomach) pain
  • An irregular or fast heartbeat
  • Dizziness or fainting
  • Extreme tiredness or fatigue
  • Sudden vision or speech changes
  • Confusion
  • Weakness or numbness on one side of the body
  • A severe headache
  • Unusual bleeding or bruising
  • Swelling in your hands, legs, ankles, or feet
  • A sudden weight gain
  • Numbness, tingling, or burning sensations in the hands or feet (neuropathy)
  • Changes in vision
  • Seizures.
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Lenalidomide Drug Information

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