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Lansoprazole Drug Interactions

Certain Diuretics 
Lansoprazole can cause low blood magnesium (hypomagnesemia). Because certain diuretics can also cause this problem, combining lansoprazole with one of these diuretics could cause severely low blood magnesium levels, which may lead to serious side effects such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking lansoprazole with one of these diuretics.
  
Erlotinib
Lansoprazole may decrease the level of erlotinib in the blood. In general, this combination should be avoided.
 
Iron
Lansoprazole may decrease the absorption of iron into the body. If you take iron for anemia, talk with your healthcare provider before taking lansoprazole.
 
Ketoconazole
Lansoprazole may decrease the absorption of ketoconazole into the body, perhaps making it less effective. Check with your healthcare provider before taking these medications together.
 
Methotrexate
Lansoprazole might increase the level of methotrexate in the blood, increasing the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications.
  
Nelfinavir
Lansoprazole may decrease the level of nelfinavir in the blood. In general, this combination should be avoided.
 
Posaconazole
Lansoprazole may decrease the level of posaconazole in the blood. In general, this combination should be avoided.
 
Tacrolimus
Lansoprazole may increase the level of tacrolimus in the blood stream. Your healthcare provider may recommend a different heartburn medication. If you must take these two medications together, your healthcare provider should carefully monitor the level of tacrolimus in your blood and adjust your tacrolimus dosage as necessary.

Lansoprazole (Prevacid)

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