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Warnings and Precautions With Ketorolac

Some Ketorolac Warnings and Precautions

Some warnings and precautions with ketorolac to be aware of include the following:
  • Ketorolac is meant for the short-term relief of pain. The medication should not be taken for more than five days.
  • There are certain other medications with which ketorolac can interact (see Drug Interactions With Ketorolac).
  • Ketorolac has been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines. These problems can lead to serious complications or even loss of life. People with a history of an ulcer in the stomach or intestines (peptic ulcer) should not take ketorolac. Contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
o Abdominal pain (or stomach pain)
o Indigestion
o Black, tarry stools
o Vomiting blood.
  • Taking ketorolac or other NSAIDs can cause kidney damage. It is more common in the elderly and people with kidney disease, heart failure, or liver problems. It is also more common in those taking diuretics or ACE inhibitors.
  • NSAIDs, including ketorolac, may cause congestive heart failure or swelling. Contact your healthcare provider if you notice unexplained weight gain or swelling. If you have heart failure, high blood pressure (hypertension), or other conditions that cause swelling, it's important that you make your healthcare provider aware of it. He or she will likely wish to use particular caution when prescribing ketorolac in your case.
  • People taking ketorolac can experience liver damage. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain (or stomach pain), or flu-like symptoms.
  • NSAIDs, including ketorolac, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice things such as hives, unexplained rash, difficulty breathing, and swelling of the face and throat.
  • In rare cases, people taking ketorolac can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the ketorolac and call your healthcare provider.
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider before starting ketorolac. Alcohol can affect the way the liver works, indirectly affecting the ketorolac.
  • NSAIDs have been known to cause an increase in liver enzymes. Therefore, your healthcare provider may recommend that you have a blood test that assesses your liver function before starting ketorolac.
  • You should not take ketorolac with any other NSAID, as this may increase your risk for serious side effects. There are many NSAIDs available with or without a prescription, so make sure to read labels carefully. Some examples of NSAIDs include ibuprofen (Motrin®, Advil®), naproxen (Naprosyn®), naproxen sodium (Aleve®, Anaprox®, Naprelan®), diclofenac (Cataflam®, Voltaren®), indomethacin (Indocin®), nabumetone (Relafen®), oxaprozin (Daypro®), celecoxib (Celebrex®), meloxicam (Mobic®), etodolac (Lodine®), ketoprofen, and others. You can ask your doctor or pharmacist for a complete list of these medications.
  • Ketorolac is a pregnancy Category C medicine, meaning that the drug could potentially cause harm to your unborn child. If you are pregnant, you should take ketorolac only if your doctor believes that the benefit of the medication outweighs the possible risk to your unborn child. Healthcare providers do not recommend ketorolac for women in the third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking ketorolac, contact your healthcare provider immediately (see Toradol and Pregnancy for more information).
  • In the past, it was strongly recommended that breastfeeding women not take this medication (the medication even had a "black box warning” to warn women). However, it is now known that the medication passes through breast milk in very low amounts, probably too low to cause problems in most cases. Nonetheless, make sure your healthcare provider knows if you are breastfeeding before you take this medication.
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