Drug Interactions With Ketorolac (Cont.)

 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Taking ketorolac and lithium together may increase the levels of lithium in your body by decreasing the removal of lithium by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
Methotrexate (Rheumatrex, Trexall)
If you are taking both methotrexate and ketorolac, your healthcare provider may monitor you more closely. He or she may need to adjust your dose of these drugs.
 
Muscle Relaxants
There have been sporadic cases of breathing problems (apnea) in people taking muscle relaxants with ketorolac. If you are taking a muscle relaxant, make sure to discuss it with your healthcare provider before starting ketorolac therapy.
 
Seizure Medicines
There have been sporadic cases of seizures reported in people taking anti-seizure medicines and ketorolac. If you are taking seizure medicines, make sure to discuss it with your healthcare provider before starting ketorolac therapy.
 
Psychoactive Drugs
There have been sporadic cases of hallucinations reported in people taking psychoactive drugs and ketorolac. If you are taking psychoactive drugs, make sure to discuss it with your healthcare provider before starting ketorolac therapy.
 
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with ketorolac and may increase the risk of bleeding. If you are taking any natural or herbal supplements, make sure to discuss this with your healthcare provider before starting ketorolac therapy.
 

Final Thoughts on Drug Interactions With Ketorolac

It is possible that not every ketorolac drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or doctor about drug interactions with ketorolac that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;