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Drug Interactions With Ivacaftor

Digoxin
Ivacaftor may increase the level of digoxin in the bloodstream. This should be taken into account when starting or stopping ivacaftor, or when changing the ivacaftor dosage. Your healthcare provider might want to check your digoxin blood levels, and may need to adjust your digoxin dosage accordingly.
 
Grapefruit or Seville Oranges
Avoid grapefruit and Seville oranges while taking ivacaftor, as these fruits and their juices may increase the level of ivacaftor in the blood.
 
Tacrolimus
Ivacaftor may increase the level of tacrolimus in the bloodstream. This should be taken into account when starting or stopping ivacaftor, or when changing the ivacaftor dosage. Your healthcare provider might want to check your tacrolimus blood levels, and may need to adjust your tacrolimus dosage accordingly.
 

Final Thoughts

It is possible that not all ivacaftor drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.

Ivacaftor Drug Information

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