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Drug Interactions With Intravenous Acetaminophen

If barbiturates, warfarin, or certain nonprescription cold medications are taken in combination with intravenous acetaminophen, drug interactions may occur. Some of these reactions can affect the level of the medications in the blood and decrease the effectiveness of the drugs or make them more toxic. To help reduce your risk for complications, make sure to tell your healthcare provider if you are taking any other medications.

An Overview of Intravenous Acetaminophen Interactions

Intravenous acetaminophen (Ofirmev™) can potentially interact with other medications. Some of these medicines that may lead to intravenous acetaminophen drug interactions include:
  • Alcohol
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
Alternative Therapies for Pain Management

IV Acetaminophen Information

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