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What Is Icatibant Used For?

How Does This Medicine Work?

HAE is caused by a defect in the gene that controls the production of a protein known as C1 inhibitor (C1-INH). C1-INH helps regulate complex reactions in the body, including reactions that control the production of a chemical known as bradykinin.
People with HAE either do not have enough C1-INH or have C1-INH that does not function properly. As a result, too much bradykinin is produced in the body. Bradykinin causes blood vessels to dilate (enlarge) and leak fluid into surrounding tissue, causing the symptoms of swelling and pain associated with HAE attacks.
Icatibant is classified as a bradykinin inhibitor. It works by blocking the action of bradykinin, thereby treating the symptoms of an HAE attack.

Can Children Use It?

Icatibant is only approved for use in individuals who are at least 18 years of age. It is not approved for use in children, as it has not been adequately studied in this age group. Talk with your child's healthcare provider about the risks and benefits of using icatibant in children.

Is It Safe for Older Adults to Use Icatibant?

There were not enough older adults in icatibant studies to determine if they would respond to icatibant any differently than younger individuals. Older adults are likely to have higher icatibant blood levels. However, dosage adjustments based on age are not recommended. Instead, there is only one standard dose of icatibant, regardless of age.

What About Off-Label Uses?

On occasion, your healthcare provider may recommend this medication for treating something other than the condition discussed in this article. This is called an "off-label" use. At this time, there are no well-accepted off-label uses for icatibant.

Icatibant Drug Information

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