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Precautions and Warnings With Icatibant

If you have recently had a heart attack or stroke, ask your healthcare provider if icatibant can increase your risk for certain complications. In some people, this drug may cause allergic reactions, drug interactions, or other potentially dangerous problems. There are also important precautions for women who are pregnant or nursing, along with warnings for people who have certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using icatibant (Firazyr®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Icatibant Precautions and Warnings

Some warnings and precautions to be aware of prior to using this medication include the following:
  • If you use this medication to treat a laryngeal (voice box or throat) attack, you should also seek immediate medical attention. Laryngeal attacks can be life-threatening.
  • You should not self-inject this medication unless your healthcare provider has shown you how to do it, and you understand the instructions exactly.
  • Do not use this medicine if your attack has progressed to the point where you cannot successfully inject it yourself. Instead, seek immediate medical attention. 
  • You may become tired, drowsy, or dizzy after using icatibant. Do not drive, use machinery, or perform any activity that requires alertness if you experience these side effects.
  • It is unknown whether icatibant is safe for use in people whose heart or brain are not getting enough oxygen-rich blood due to a blockage of the blood vessels (known medically as ischemia), such as during a heart attack or stroke. Let your healthcare provider know if you have recently had a stroke or heart attack, or if you have chest pain (which could be a sign of ischemia).
  • Icatibant is a pregnancy Category C medication, which means it may not be safe for use during pregnancy (see Firazyr and Pregnancy).
  • It is unknown whether icatibant passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Firazyr and Breastfeeding).

Icatibant Drug Information

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