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Precautions and Warnings With Granisetron

There are many precautions and warnings with granisetron to be aware of, including possible side effects that may occur. Let your healthcare provider know if you have any allergies or liver disease before taking the drug. You should avoid taking granisetron altogether if you are allergic to any components of the medicine. Talking to your healthcare provider about granisetron warnings and precautions can help minimize risks.

What Should I Tell My Healthcare Provider Before Taking Granisetron?

You should talk with your healthcare provider prior to taking granisetron hydrochloride (Kytril®) if you have:


Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Granisetron

Warnings and precautions to be aware of prior to taking granisetron include the following:
  • There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking granisetron. This heart rhythm change can be dangerous. People with heart disease or an electrolyte imbalance may be at a higher risk for this problem. Taking granisetron with certain other medications may also increase this risk (see Drug Interactions With Granisetron).  


  • If you have liver disease, your body may not metabolize granisetron as well as it should. Therefore, you may require extra monitoring by your healthcare provider and you may need to take a lower granisetron dosage. However, most people with liver problems do not need a lower granisetron dosage.
  • Granisetron is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Kytril and Pregnancy).
  • It is not known if granisetron passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Kytril and Breastfeeding).
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Granisetron Hydrochloride (HCl) -- Drug Information

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