Drug Interactions With Granisetron Transdermal

Certain medicines can cause drug interactions with granisetron transdermal patches, including ketoconazole and phenobarbital. Taking these medicines with granisetron transdermal can reduce the effectiveness of the drugs or increase your risk of developing side effects. To help prevent negative drug interactions, talk to your healthcare provider before using any other medications.

An Overview of Granisetron Transdermal Drug Interactions

Granisetron transdermal (Sancuso®) can potentially interact with a few other medications. Some of these medicines that might lead to interactions include:
 
  • Ketoconazole (Nizoral®)
  • Phenobarbital (Luminal®).
     

Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when granisetron transdermal is combined with any of the drugs listed above.
 
Ketoconazole (Nizoral)
Ketoconazole may decrease the ability of your liver to metabolize granisetron transdermal, which could increase the level of granisetron transdermal in your blood. This could increase your risk of granisetron transdermal side effects. The significance of this interaction is not yet known. Talk to your healthcare provider before using these medications together.
 
Phenobarbital (Luminal)
Studies have shown that phenobarbital can decrease the level of granisetron (the active ingredient in granisetron transdermal), perhaps making it less effective. Your healthcare provider may need to adjust your granisetron transdermal dosage, although this may not be necessary.
 

Final Thoughts on Granisetron Transdermal Drug Interactions

It is possible that not all granisetron transdermal drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interaction with granisetron transdermal that may apply to you.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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