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Drug Interactions With Gemfibrozil

Warfarin (Coumadin, Jantoven)
Gemfibrozil can increase the anticoagulant (anti-clotting) effect of warfarin. This means that you are at an increased risk of bleeding if you are taking both gemfibrozil and warfarin. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments. INR and prothrombin time are tests used to measure how well your blood is clotting.
HMG-CoA Reductase Inhibitors (Statins)
The use of gemfibrozil with a statin medication should generally be avoided due to the increased risk of kidney and muscle problems. This combination should be used only if the benefit of further lowering cholesterol levels outweighs the risk.
Gemfibrozil should never be combined with simvastatin, in particular.
(Click Lopid and Muscle Pain for more information.)
Repaglinide (Prandin)
Gemfibrozil can cause an increase in the levels of repaglinide found in the blood. Repaglinide is a medication used to treat diabetes, and high levels are associated with severe, prolonged hypoglycemia (low blood sugar). Therefore, these medications should not be taken together.
Bexarotene (Targretin)
Gemfibrozil can cause an increase in the levels of bexarotene found in the blood. Bexarotene is an anti-cancer medication, and some common side effects include elevated cholesterol and triglyceride levels. Therefore, this combination is not recommended.
Ezetimibe (Zetia)
The use of gemfibrozil with ezetimibe is not recommended due to a lack of clinical studies on this drug combination. The combination of these two medications may increase a person's risk of developing gallstones.
Colchicine (Colcrys)
The use of gemfibrozil with colchicine increases the risk of kidney and muscle problems. Elderly people and those with kidney problems are at an even higher risk of such problems.
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Gemfibrozil Information

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