HMG-CoA Reductase Inhibitors (Statins)
The use of
gemfibrozil with a statin medication should generally be avoided due to the increased risk of kidney and muscle problems. This combination should be used only if the benefit of further
lowering cholesterol levels outweighs the risk.
Repaglinide (Prandin)
Gemfibrozil can cause an increase in the levels of
repaglinide found in the blood. Repaglinide is a medication used to treat
diabetes, and high levels are associated with severe, prolonged hypoglycemia (low blood sugar). Therefore, this combination should generally be avoided.
Bexarotene (Targretin)
Gemfibrozil can cause an increase in the levels of bexarotene found in the blood. Bexarotene is an anti-cancer medication, and some common side effects include elevated
cholesterol and
triglyceride levels. Therefore, this combination is not recommended.
Ezetimibe (Zetia)
The use of gemfibrozil with
ezetimibe is not recommended due to a lack of clinical studies on this drug combination. The combination of these two medications may increase a person's risk of developing gallstones.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can make it harder for gemfibrozil to be eliminated from the body. If you are taking both gemfibrozil and cyclosporine, you may be at increased risk of developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments.
Drug Interactions With Gemfibrozil: Summary
It is possible that not every potential gemfibrozil drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or doctor about possible drug interactions with gemfibrozil that may apply to you.
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