When determining your Gablofen dosage, your healthcare provider will need to try some test doses to see how you respond to the medication. He or she can gradually increase the amount until a desired effect is achieved without intolerable side effects. However, if several test doses do not provide an adequate response, Gablofen may not be the best option for you.
The dosage of Gablofen® (baclofen) your healthcare provider recommends will vary, depending on a number of factors, including:
- How you respond to Gablofen
- Other medications you are taking
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
There is a specific protocol that must be followed when determining an appropriate dosage for Gablofen intrathecal infusion (in which the medication is delivered directly into the spinal cord via a pump).
First, a "test dose" of 50 mcg is given to make sure that the medication is actually going to work. This is given by an injection directly into the intrathecal space around the spinal cord. If no response is seen, a second, higher test dose of 75 mcg may be given 24 hours later. If the response is still inadequate, a third test dose of 100 mcg can be tried 24 hours later. If the response is still inadequate, Gablofen is probably not an appropriate treatment option.
For children, the same test protocol is used; however, a lower starting test dose of 25 mcg may be more appropriate for younger children.
The starting dosage for actual use in the pump will be based on the response to the test dose. The amount will then be gradually increased until the desired result is achieved. The "maintenance" dosage may occasionally need to be adjusted, especially during the first few months of use, in order to achieve a good balance between effectiveness and undesirable side effects.
The specific way and frequency of refilling the pump reservoir will vary, depending on the particular type of pump used.