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Precautions and Warnings With Gabapentin Enacarbil

Before using gabapentin enacarbil, tell your doctor if you have any other medical conditions, such as depression, kidney disease, or any allergies. Gabapentin enacarbil is not suitable for everyone, so the warnings and precautions should be reviewed with your healthcare provider to lower your risk of problems. Certain people, such as those who are allergic to any of the drug's ingredients, should avoid it completely.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking gabapentin enacarbil (Horizant™) if you have:
 
  • Depression
  • A history of suicidal thoughts or actions
  • Kidney disease, such as kidney failure (renal failure)
  • Cancer
  • Any allergies, including to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Gabapentin Enacarbil Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Make sure you know how gabapentin enacarbil affects you before driving or operating any machinery, as it can cause drowsiness and dizziness.
 
  • In general, you should avoid alcohol while taking this medicine, due to the risk of increased drowsiness.
 
  • Gabapentin enacarbil increases the risk of certain cancers in rats. It is not known if it also increases the risk of cancer in humans.
     
  • Gabapentin enacarbil is not interchangeable with other forms of gabapentin, such as Neurontin® or Gralise™. If you switch from one gabapentin product to another, your dosage may need to be adjusted.
     
  • Let your healthcare provider know if you have kidney disease. A lower dosage may be recommended.
     
  • For people taking this drug once daily, this medication can be stopped abruptly if necessary. For people taking it twice daily, the medication should be stopped gradually. Abruptly stopping this medication may increase the risk for seizures.
     
  • Gabapentin enacarbil can react with other medications (see Drug Interactions With Gabapentin Enacarbil).
     
  • This medication is considered a pregnancy Category C drug. This means that it may not be safe for pregnant women, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of taking the drug during pregnancy (see Horizant and Pregnancy).
     
  • Gabapentin enacarbil passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Horizant and Breastfeeding).
     
Know the Signs - Concussion Safety

Gabapentin Enacarbil Drug Information

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