Drug Interactions With Fondaparinux

Several medications can cause negative drug interactions with fondaparinux, including certain blood thinners, ibritumomab, and dasatinib. Some of these interactions can increase your risk of dangerous internal bleeding. To help avoid any complications, make sure your healthcare provider is aware of any other medications you are taking, including vitamins, herbal supplements, and nonprescription medicines.

Fondaparinux Drug Information

An Overview of Fondaparinux Interactions

Fondaparinux sodium (Arixtra^®) may potentially interact with other medications. Some of the medications that may lead to fondaparinux drug interactions include but are not limited to:

Dasatinib (Sprycel^®)
Drotrecogin alfa (Xigris^®)
Ibritumomab (Zevalin^®)
Pentosan polysulfate sodium (Elmiron^®)
Tositumomab (Bexxar^®)
Other medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
- Aspirin (Bayer^® and others)
- Cilostazol (Pletal^®)
- Clopidogrel (Plavix^®)
- Dabigatran etexilate mesylate (Pradaxa^®)
- Dipyridamole (Persantine^®)
- Eptifibatide (Integrilin^®)
- Heparin or heparin-like products, including enoxaparin (Lovenox^®), dalteparin (Fragmin^®), or tinzaparin (Innohep^®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

Celecoxib (Celebrex^®)
Diclofenac (Cataflam^®, Voltaren^®)
Etodolac (Lodine^®)
Ibuprofen (Motrin^®, Advil^®)
Indomethacin (Indocin^®)
Ketoprofen (Orudis^®)
Ketorolac (Toradol^®)
Meloxicam (Mobic^®)
Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
Nabumetone (Relafen^®)
Oxaprozin (Daypro^®)

Prasugrel (Effient^®)

Rivaroxaban (Xarelto^®)

Thrombolytics, such as:

Alteplase (Activase^®)
Reteplase (Retavase^®)
Streptokinase (Streptase^®)
Tenecteplase (TNKase^®)

Ticagrelor (Brilinta™)
Ticlopidine (Ticlid^®)
Tirofiban (Aggrastat^®)
Warfarin (Coumadin^®, Jantoven^®).

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