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Precautions and Warnings of Fluvastatin

Understanding warnings and precautions with fluvastatin before starting treatment can help you determine whether the drug is suitable for you and minimize risks. Because drug interactions are possible, tell your healthcare provider about all other medications you are taking. People who should not take fluvastatin include women who are pregnant or breastfeeding, people who are allergic to fluvastatin sodium, and those who have active liver disease.

Fluvastatin: What Should I Tell My Healthcare Provider?

Prior to taking fluvastatin (Lescol®) or fluvastatin extended-release (Lescol® XL), you should talk with your healthcare provider if you have:
  • Liver disease or liver failure
  • Kidney disease or kidney failure
  • Any allergies, including allergies to foods, dyes, or preservatives. 
Let your healthcare provider know if you:
  • Are pregnant or thinking about becoming pregnant
  • Are breastfeeding
  • Drink alcohol frequently.
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, antacids, vitamins, and herbal supplements.
Finally, make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if you also have body aches or a fever.

Specific Precautions and Warnings of Fluvastatin

Warnings and precautions to be aware of prior to taking fluvastatin include the following:
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to taking this drug. Alcohol can affect the way the liver works, indirectly affecting the fluvastatin.
  • Statins have been known to cause an increase in liver enzymes. Therefore, you should have a blood test that looks at your liver function before starting fluvastatin. These tests may also be recommended if your doctor changes your dosage (see Lescol and Liver Problems).
Previously it had been recommended that people taking statins have routine periodic liver function tests while taking the medication, but this recommendation has been removed, since such monitoring does not help much to detect or prevent such problems. Liver function tests should still be performed if there is any suspicion of liver damage. 
  • Rhabdomyolysis (the severe breakdown of muscles) and other serious muscle problems have rarely been reported with fluvastatin and other statins. You are at greater risk for developing muscle problems with this drug if you:
    • Have kidney damage
    • Are elderly
    • Are not being properly treated for hypothyroidism.
  • Make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if you also have a fever or feel ill (see Lescol and Muscle Pain).
  • Fluvastatin is a pregnancy Category X medicine, meaning that it could potentially cause harm to your unborn child. The safety of this drug in pregnant women has not been established. If you are pregnant, talk to your healthcare provider immediately (see Lescol and Pregnancy).
  • If you are nursing, it is not known whether fluvastatin passes through your milk. Therefore, ask your healthcare provider whether you should stop nursing or discontinue fluvastatin.
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