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Drug Interactions With Fluvastatin

More Information on Interactions With Fluvastatin

The following sections explain in detail the potentially negative interactions that can occur when fluvastatin is combined with any of the drugs listed above.
 
Colchicine
There have been reports of muscle problems in people who combined fluvastatin with colchicine. Talk to your healthcare provider before combining these medications. If you are taking these medications together, let your healthcare provider know immediately if you develop any muscle pain or weakness.
 
Cholestyramine (Questran, LoCholest, Prevalite)
Cholestyramine can bind to fluvastatin in your digestive tract, preventing it from being absorbed into your body. This may make fluvastatin less effective. In order to decrease the chances of this drug interaction, it is recommended that you take fluvastatin at bedtime, at least two hours after taking cholestyramine.
 
Cimetidine (Tagamet)
Taking cimetidine and fluvastatin together may increase the level of fluvastatin in your blood, increasing your risk of side effects of fluvastatin. Your healthcare provider may need to adjust your fluvastatin dosage or may recommend one of the many cimetidine alternatives.
 
In addition, both cimetidine and fluvastatin can decrease the level of hormones in your body. Taking them together may theoretically increase your chance of problems due to low hormones.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Combining cyclosporine and fluvastatin may increase the level of fluvastatin in the blood. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis (see Lescol and Muscle Pain). Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
 
Diclofenac (Cataflam, Voltaren)
Taking diclofenac and fluvastatin together may cause the levels of diclofenac in the blood to be significantly higher than intended. Your healthcare provider may need to lower your diclofenac dosage to prevent this interaction.
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