Drug Interactions With Fluvastatin (Cont.)

Fluvastatin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when fluvastatin is combined with any of the drugs listed above.
 
Colchicine
There have been reports of muscle problems in people who combined fluvastatin with colchicine. Talk to your healthcare provider before combining these medications. If you are taking these medications together, let your healthcare provider know immediately if you develop any muscle pain or weakness.
 
Cholestyramine (Questran, LoCholest, Prevalite)
Cholestyramine can bind to fluvastatin in your digestive tract, preventing it from being absorbed into your body. This may make fluvastatin less effective. In order to decrease the chances of this occurring, it is recommended that you take fluvastatin at least two hours after taking cholestyramine.
 
Cimetidine (Tagamet)
Taking cimetidine and fluvastatin together may increase the level of fluvastatin in your blood, increasing your risk of fluvastatin side effects. Your healthcare provider may need to adjust your fluvastatin dosage or may recommend one of the many cimetidine alternatives.
 
Additionally, both cimetidine and fluvastatin can decrease the level of hormones in your body. Taking them together may increase your chance of problems due to low hormones.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Taking cyclosporine and fluvastatin simultaneously may cause your body to metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk for developing serious muscle problems, such as myopathy or rhabdomyolysis (see Lescol and Muscle Pain). Your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments.
 
Diclofenac (Cataflam, Voltaren)
Taking diclofenac and fluvastatin together may cause the levels of diclofenac in the blood to be significantly higher than intended. Your healthcare provider may need to lower your diclofenac dosage.
(Drug Interactions With Fluvastatin Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;