Drug Interactions With Fluticasone Propionate Nasal Spray

Protease inhibitors and certain antibiotics or antifungals can cause drug interactions with fluticasone propionate nasal spray. When these medicines interact with the nasal spray, the level of fluticasone propionate in your blood may increase, which could lead to potentially serious side effects or complications. To help prevent fluticasone propionate nasal spray interactions, make sure your healthcare provider knows about all other drugs you are taking.

 

Fluticasone Propionate Nasal Spray Drug Interactions: An Overview

Fluticasone propionate nasal spray (Flonase®) can potentially interact with other medications. Some of these medicines that may lead to fluticasone propionate nasal spray drug interactions include:
 
  • Certain antibiotics or antifungals, including:
o Clarithromycin (Biaxin®)
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Telithromycin (Ketek®)
  • Protease inhibitors, such as:

Fluticasone Propionate Nasal Spray Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when fluticasone propionate nasal spray is combined with any of the drugs listed above.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;