Fluconazole Side Effects

Although most people respond well to fluconazole, side effects are possible. In clinical studies, some of the most common problems that were reported with this medication included diarrhea, headache, abdominal pain, and nausea. While most side effects are minor, some are potentially serious and should be reported to your healthcare provider right away, including seizures, dark urine, and breathing problems.

An Introduction to Fluconazole Side Effects

As with any medicine, side effects are possible with fluconazole (Diflucan®). However, not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with fluconazole. Your healthcare provider can discuss a more complete list of fluconazole side effects with you.)
 

Serious Side Effects Seen With Fluconazole

Some fluconazole side effects are serious -- even life-threatening -- and should be reported to your healthcare provider. These include but are not limited to:
 
  • Signs of liver damage, such as:
 
    • Yellow eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • Elevated liver enzymes (found using a standard blood test)
 
  • An irregular heart rhythm (arrhythmia)
  • Seizures
  • Signs of an allergic reaction, such as:
 
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling (especially of the lips, mouth, or throat)
    • Wheezing or other breathing problems.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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