You should talk with your healthcare provider prior to taking fluconazole if you have:
- Liver disease, such as liver failure, hepatitis, or cirrhosis
- Heart disease
- An irregular heart rhythm
- Long QT syndrome
- An electrolyte imbalance
- Any other allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Diflucan and Pregnancy)
- Breastfeeding (see Diflucan and Breastfeeding).
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Fluconazole to learn more, including information on who should not take the drug.)
Fluconazole belongs to a group of medications known commonly as "azole" antifungals. It works by inhibiting an enzyme that is used by fungal cells to make ergosterol, an important component of the fungal cell membrane. As a result, there is not enough ergosterol and too much of the compounds that are normally used to make it, and fungal growth is inhibited.
Some general considerations for those taking fluconazole include the following:
- Fluconazole comes in tablet, suspension (oral liquid), and injectable form.
- Unlike most other yeast infection medications, fluconazole is not used vaginally. It works through the bloodstream to treat yeast infections.
- You can take this drug either with or without food and at any time of the day.
- Be sure to shake the oral suspension well before each dose.
For the medication to work properly, it must be taken as prescribed.