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Drug Interactions With Fluconazole

Pimozide
Combining pimozide with fluconazole may increase the risk of a dangerous irregular heart rhythm (arrhythmia). These medicines typically should not be taken together.
 
Quinidine
Fluconazole may increase the level of quinidine in the blood, perhaps increasing the risk of dangerous side effects. If you must take these medications together, your healthcare provider should monitor you closely and adjust your quinidine dosage as necessary.
 
Quinine
Combining quinine with fluconazole may increase the risk of a dangerous irregular heart rhythm (arrhythmia). In general, these drugs should not be taken together.
 
Ranolazine
In most cases, people should avoid combining azole antifungals like fluconazole with ranolazine, as this combination may result in increased levels of ranolazine in the blood.
 
Rifabutin
Combining rifabutin and fluconazole can increase the level of rifabutin in the blood, decrease the level of fluconazole in the blood, and increase the risk of inflammation of the middle layer of the eye (uveitis).
 
Rifampin
Rifampin decreases the level of fluconazole in the blood, potentially making it less effective. In some situations, your healthcare provider may decide to recommend a higher fluconazole dosage to account for this drug interaction.
 
Sulfonylureas
Fluconazole may increase the level of sulfonylurea medications in the bloodstream and could, therefore, cause dangerously low blood sugar (hypoglycemia). If you take these medications together, you must monitor your blood sugar more frequently, and your healthcare provider may need to adjust the dosage of your sulfonylurea.
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Fluconazole Drug Information

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