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Drug Interactions With Fluconazole

More Information on Interactions With Fluconazole

The following sections explain in detail the potentially negative interactions that can occur when fluconazole is combined with any of the drugs listed above.
 
Certain Benzodiazepines
Fluconazole may increase the level of many benzodiazepines in the blood, increasing the risk of serious side effects. Your healthcare provider may decide to lower your benzodiazepine dosage or even avoid this combination altogether in some situations.
 
Cisapride
Cisapride and fluconazole should never be taken together, due to the risk of a dangerous irregular heart rhythm known as torsade de pointes.
 
Conivaptan
The combination of conivaptan and fluconazole should be avoided, since fluconazole may substantially increase the level of conivaptan in the blood.
 
Cyclosporine
Fluconazole increases the level of cyclosporine in the bloodstream. If you must take these medications together, your healthcare provider should monitor your cyclosporine levels and adjust your dosage as necessary.
 
Dofetilide
In general, azole antifungals like fluconazole should not be taken with dofetilide, as this combination may result in increased levels of dofetilide in the blood.
 
Nilotinib
Combining nilotinib with fluconazole may increase the risk of a dangerous irregular heart rhythm (arrhythmia). In general, these medications should not be taken together.
 
Phenytoin
Fluconazole increases the level of phenytoin in the bloodstream. If you take these medications together, your healthcare provider should monitor your phenytoin levels and adjust your dosage as necessary.
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Fluconazole Drug Information

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