• There are certain other medications that fexofenadine and pseudoephedrine can interact with (see Drug Interactions With Fexofenadine and Pseudoephedrine).
   
• Fexofenadine and pseudoephedrine should not be used with other antihistamines or decongestants.
   
• Although fexofenadine and pseudoephedrine causes drowsiness less often than other antihistamines, it may still make some people tired. Therefore, until you know whether fexofenadine and pseudoephedrine makes you tired, caution should be used before driving a car or operating potentially dangerous machinery.
   
• Fexofenadine and pseudoephedrine is a pregnancy Category C medicine, meaning that it could potentially harm your unborn child. If you are pregnant, you should only take fexofenadine and pseudoephedrine if the benefit outweighs the possible risk to your unborn child. Discuss the safety with your healthcare provider before using fexofenadine and pseudoephedrine.
   
• If you are nursing or plan to nurse, it is important to know that fexofenadine and pseudoephedrine passes through your milk. Therefore, if you are taking fexofenadine and pseudoephedrine, it is recommended that you stop until talking your doctor.
   

• Are allergic to fexofenadine or pseudoephedrine, Allegra-D, Allegra, adrenergic agents, or any of the inactive components used in making the medicines. Your healthcare provider or pharmacist has a list of the inactive ingredients.
   
• Have narrow-angle glaucoma.
   
• Have urinary blockage or difficulty urinating.
   
• Are taking an MAO inhibitor or have taken an MAO inhibitor within the last 14 days. MAO inhibitors are medicines used to treat depression. Some examples of MAO inhibitors include:

o Isocarboxazid (Marplan^®)

o Phenelzine (Nardil^®)

o Selegiline (Eldepryl^®, EMSAM^®)

o Tranylcypromine (Parnate^®).

• Have severe high blood pressure (hypertension).
   
• Have severe coronary heart disease.