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Fexofenadine and Pseudoephedrine

How Does Fexofenadine and Pseudoephedrine Work?

When you come in contact with something you're allergic to, a chain reaction begins inside your body. During this chain reaction, special cells release powerful chemicals. Some of these chemicals can trigger swelling of the nasal passages, leading to nasal congestion (a "stuffy nose"). Other chemicals, such as histamine, can cause sneezing, itching, and irritation.
 
Fexofenadine and pseudoephedrine is a combination medication. Fexofenadine (Allegra®) is part of a class of drugs called antihistamines. Allegra blocks the effects of histamine (hence its classification as an antihistamine). This leads to the relief of allergy symptoms -- except for nasal congestion. Pseudoephedrine (the most common brand name being Sudafed®) is a decongestant. It works by decreasing the swelling in the nasal passages, which improves the nasal congestion.
 

Effects of Fexofenadine and Pseudoephedrine

Prior to the drug's approval in the United States, one clinical study was conducted on 651 adults and adolescents. In this study, people taking fexofenadine and pseudoephedrine had improved allergy relief compared to the group of people not taking the medicine. This improvement was measured based on a symptom score that looked at changes in the following allergy symptoms:
 
  • Sneezing
  • Runny nose
  • Itchy nose and/or throat
  • Itchy, watery, and/or red eyes
  • Nasal congestion.
     
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Fexofenadine and Pseudoephedrine Medicine

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