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Drug Interactions With Fexofenadine and Pseudoephedrine
When various medications are taken together, there is a potential for developing certain drug interactions. With fexofenadine and pseudoephedrine, an interaction can occur if it is taken with medicines such as ketoconazole, beta blockers, erythromycin, or mecamylamine. Drug interactions with fexofenadine and pseudoephedrine can cause your body to metabolize the medicines differently than intended and lead to problems such as increased drug levels in your system or reduced effectiveness of the drugs.
Fexofenadine and pseudoephedrine (Allegra-D®) has a number of other medicines that it can potentially interact with. Some possible fexofenadine and pseudoephedrine drug interactions can include:
- Ketoconazole (Nizoral®)
- Erythromycin (Ery-Tab®, ERYC®, Erythrocin, E.E.S)
- Antacids containing aluminum and magnesium, such as Maalox® or Mylanta®
- Digoxin (Digitek®, Lanoxin®, Lanoxicap®)
- Beta blockers, such as metoprolol (Lopressor®), atenolol (Tenormin®), propranolol (Inderal®), or metoprolol succinate (Toprol XL®)
- Methyldopa (Aldomet®)
- Mecamylamine (Inversine®)
- Reserpine (Serpalan®, Serpasil®).
Fexofenadine and Pseudoephedrine Interactions Explained
Ketoconazole (Nizoral)
Taking ketoconazole with fexofenadine and pseudoephedrine may cause your body to metabolize the medicines differently than intended. This can result in an increased amount of fexofenadine and pseudoephedrine in your body. If you are taking these medications together, your healthcare provider may choose to monitor you more closely and make necessary dosing adjustments.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD