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Side Effects of Fentanyl Sublingual Tablets

Common Side Effects

Fentanyl sublingual tablets have been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully recorded. In all the studies, long-acting opioid narcotics were used in addition to fentanyl sublingual tablets. Therefore, it can be difficult to know whether any adverse reactions were due to the tablets or the other opioid medication.
In clinical studies, the most common fentanyl sublingual tablet side effects included:
  • Nausea -- in up to 6.0 percent of people
  • Constipation -- up to 4.8 percent
  • Headaches -- up to 3.0 percent
  • Drowsiness -- up to 4.4 percent
  • Dizziness -- up to 2.2 percent
  • Redness, swelling, and inflammation of the lining of the mouth -- up to 1.8 percent
  • Tiredness (fatigue) -- up to 1.8 percent
  • Dry mouth -- up to 1.8 percent
  • A bad taste in the mouth -- up to 1.2 percent
  • Excessive sweating -- up to 1.2 percent.
Other side effects that occurred in at least 1 percent of people given fentanyl sublingual tablets in clinical trials included:
  • A fast or slow heart rate
  • Blurred vision
  • Abdominal (stomach) pain
  • Sores or ulcers on the lining of the mouth, lips, or tongue
  • Shortness of breath
  • Indigestion or heartburn
  • Vomiting
  • Delayed stomach emptying
  • Weakness or lack of energy
  • General feelings of discomfort
  • Accidental overdose
  • Decreased or loss of appetite
  • Memory problems
  • Reduced sense of touch
  • Abnormal sense of smell
  • Shakiness (tremors)
  • Problems sleeping
  • Erectile dysfunction (ED) or impotence
  • Throat pain or tightness
  • Itching
  • Rash
  • Night sweats
  • Decreased blood pressure (hypotension).
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Fentanyl Sublingual Tablet Information

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