Drug Interactions With Fentanyl Sublingual Tablets

Taking certain medications with fentanyl sublingual tablets may result in potentially dangerous complications. Some of these interactions can increase your risk for side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, amphetamines, and antidepressants are among the products that can lead to drug interactions with fentanyl sublingual tablets.

An Overview of Fentanyl Sublingual Tablet Interactions

 Fentanyl sublingual tablets (Abstral®) are a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This medication may react with many other products.
 
Some of the drugs that may lead to interactions with fentanyl include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Drug Interactions With Fentanyl Sublingual Tablets Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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