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Drug Interactions With Fentanyl Sublingual Tablets

CYP 3A4 Inhibitor Medications
The body breaks down fentanyl sublingual tablets using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining these tablets with one of these drugs may increase the level of fentanyl in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you take fentanyl sublingual tablets with a CYP 3A4 inhibitor.
 
Desmopressin
Fentanyl sublingual tablets can increase the risk for desmopressin side effects. Do not combine these drugs without first speaking with your healthcare provider.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using this medication.
 
Medications That Cause Drowsiness
Fentanyl sublingual tablets cause significant drowsiness. Taking other medications that cause drowsiness with these tablets may lead to serious side effects, such as extreme sedation, confusion, and breathing problems. Check with your healthcare provider before taking fentanyl sublingual tablets with other medications that may cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl sublingual tablets with an MAOI may cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use these tablets if you have taken an MAOI within the past 14 days.
 
Octreotide
Combining octreotide with fentanyl sublingual tablets may increase the pain-relieving effects of the tablets. Your healthcare provider may monitor your pain response if you take these medications together. You might need a lower dosage of fentanyl sublingual tablets.
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Fentanyl Sublingual Tablet Information

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