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Drug Interactions With Fentanyl Sublingual Tablets

Drug Interactions With Fentanyl Sublingual Tablets Explained

The following sections explain in detail the potentially negative interactions that can occur when fentanyl sublingual tablets are combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while taking fentanyl sublingual tablets could potentially increase your risk for serious side effects, including extreme drowsiness, confusion, or difficulty breathing. You should not drink alcohol while using this medication.
 
Alvimopan
Fentanyl sublingual tablets may increase the risk for serious alvimopan side effects. Do not take alvimopan if you have used fentanyl sublingual tablets in the past seven days.
 
Amphetamines
Combining amphetamines with fentanyl sublingual tablets may increase the pain-relieving effects of the tablets. Your healthcare provider may choose to monitor your response if you take these drugs together. You might need a lower fentanyl sublingual tablets dosage.
 
Beta Blockers
Taking fentanyl sublingual tablets with a beta blocker may lower your heart rate and blood pressure to potentially unsafe levels. If you take these medications together, your healthcare provider may need to monitor your blood pressure and heart rate more closely.
 
Calcium Channel Blockers
Taking fentanyl sublingual tablets with certain calcium channel blockers may lower your heart rate and blood pressure to potentially unsafe levels. Your healthcare provider may need to monitor your blood pressure and heart rate more closely if you take these medications together.
 
CYP 3A4 Inducer Medications
The body breaks down fentanyl sublingual tablets using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining these tablets with one of these drugs may decrease the level of fentanyl in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure your pain is adequately controlled if you take fentanyl sublingual tablets with a CYP 3A4 inducer.
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Fentanyl Sublingual Tablet Information

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