Drug Interactions With Fentanyl Lozenge

Alcohol, amphetamines, and sleep medications are just a few of the products that can react with fentanyl lozenges. These drug interactions could increase your risk for serious side effects, such as extreme drowsiness, memory loss, and difficulty breathing. To reduce the risk of reactions with these lozenges, talk to your healthcare provider about any other medications you are taking (including nonprescription medications).

An Overview of Fentanyl Lozenge Interactions

The
 fentanyl lozenge (Actiq®) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may potentially interact with many other medications.
 
Some of the medications that may lead to fentanyl lozenge drug interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Drug Interactions With Fentanyl Lozenge Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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