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Drug Interactions With Fentanyl Lozenge

CYP 3A4 Inhibitor Medications
The body breaks down the fentanyl lozenge using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining a fentanyl lozenge with one of these CYP 3A4 inhibitors may increase the level of fentanyl in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you use a fentanyl lozenge with a CYP 3A4 inhibitor.
 
Desmopressin
Fentanyl lozenges can increase the risk of desmopressin side effects. Talk to your healthcare provider prior to using these medications together.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using fentanyl lozenges.
 
Medications That Cause Drowsiness
Fentanyl lozenges cause significant drowsiness. Taking other medications that cause drowsiness while using these lozenges may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before using a fentanyl lozenge with other medications that can cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining a fentanyl lozenge with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use this lozenge if you have taken an MAOI within the past 14 days.
 
Octreotide
Combining octreotide with a fentanyl lozenge may increase the pain-relieving effects of the lozenge. Your healthcare provider may monitor your pain response if you use these medications together. You might need a lower fentanyl lozenge dosage.
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Fentanyl Lozenge Drug Information

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