Drug Interactions With Fentanyl Buccal Soluble Film

Taking certain medications with fentanyl buccal soluble film may result in dangerous (and even life-threatening) complications. Some of these interactions can increase your risk for side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, antihistamines, and grapefruit juice are among the products that can lead to negative drug interactions with fentanyl buccal soluble film.

An Overview of Fentanyl Buccal Soluble Film Interactions

 Fentanyl buccal soluble film (Onsolis™) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may react with many other medications.
 
Some of the drugs that may lead to interactions with fentanyl buccal soluble film include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Drug Interactions With Fentanyl Buccal Soluble Film Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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