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Drug Interactions With Fentanyl Buccal Soluble Film

CYP 3A4 Inhibitor Medications
The body breaks down fentanyl buccal soluble film using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining fentanyl buccal soluble film with one of these drugs may increase the level of fentanyl in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing problems. Your healthcare provider may monitor you more closely for side effects if you use these medications together.
 
Desmopressin
Fentanyl buccal soluble film can increase the risk for desmopressin side effects. Do not use these drugs together without first talking to your healthcare provider about this potential interaction.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl buccal soluble film in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using fentanyl buccal soluble film.
 
Medications That Cause Drowsiness
Fentanyl buccal soluble film causes significant drowsiness. Combining it with other medications that cause drowsiness may lead to serious side effects, including extreme sedation, confusion, and breathing problems. Check with your healthcare provider before using fentanyl buccal soluble film with other medications that cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl buccal soluble film with an MAOI may cause a potentially dangerous reaction known as serotonin syndrome. It may also lead to low blood pressure. Do not use fentanyl buccal soluble film if you have taken an MAOI within the past 14 days.
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Fentanyl Buccal Soluble Film Information

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