Many people wonder, "What is ezetimibe used for?" Ezetimibe is a prescription drug that is used to treat high cholesterol and a rare genetic condition called sitosterolemia. The medication works by blocking the absorption of cholesterol from the intestines into the blood. It is effective at lowering total cholesterol and "bad cholesterol" -- and can also slightly decrease triglycerides -- but has little effect on "good cholesterol" by itself. In people with sitosterolemia, ezetimibe is used to treat high levels of sitosterol and campesterol in the blood. Ezetimibe has been approved for use in adults and adolescents 10 years of age and older.