• There are certain other medications that ezetimibe can interact with (see Drug Interactions With Ezetimibe).
   
• Cholesterol-reducing medications have been known to cause an increase in liver enzymes. This is especially true of statins (certain cholesterol medications often combined with ezetimibe). Your healthcare provider may check your liver function using a simple blood test to measure your liver enzymes, especially if you take ezetimibe with a statin.
   
• In very rare cases, people taking ezetimibe may develop serious problems in their muscles. These problems can lead to life-threatening complications. Therefore, make sure to contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness, especially if it is accompanied by a fever or feeling of illness (see Zetia and Muscle Pain).
   
• Ezetimibe is a pregnancy Category C medicine. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Zetia and Pregnancy).
   
• It is not known whether ezetimibe is excreted in breast milk. If you are breastfeeding and taking ezetimibe, talk with your healthcare provider about whether you should continue the medicine (see Zetia and Breastfeeding).
   

• You are allergic to ezetimibe or any component of ezetimibe or Zetia. Your healthcare provider or pharmacist has a list of the inactive ingredients.
   
• You have active liver disease or unexplained high liver enzymes.

 

• Are pregnant or breastfeeding (this applies only to those who take ezetimibe plus a statin medication).