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Effects of Ezetimibe/Simvastatin

In research studies, people taking ezetimibe/simvastatin 10/20 mg once in the evening were able to, on average, decrease LDL cholesterol by 52 percent, total cholesterol by 36 percent, and triglycerides by 24 percent. HDL increased by 10 percent. The effects of ezetimibe/simvastatin on cholesterol and triglyceride levels were generally greater with higher doses.

When and How Do I Take It?

Some general considerations for when and how to take ezetimibe/simvastatin include the following:
  • The medication should be taken in the evening.
  • Your ezetimibe/simvastatin dosage may be taken with or without food.
  • To maintain even levels of the drug in your body, make sure to take ezetimibe/simvastatin at the same time each day.
  • For ezetimibe/simvastatin to work properly, you have to take it as prescribed. The medication will not work if you stop taking it. 


Dietary Instructions

People who are taking ezetimibe/simvastatin are typically advised to avoid grapefruit juice because it can increase the levels of simvastatin in the blood, which can increase the risk of developing serious muscle problems. If you are being treated with this medication and want to continue drinking grapefruit juice, talk to your doctor about other cholesterol-lowering medications you can take.
(Click Grapefruit Juice and Vytorin for more information.)
As with any cholesterol medication, you should continue to eat a low-fat, low-cholesterol diet as part of your treatment program to lower cholesterol.
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Ezetimibe and Simvastatin Drug Information

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