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Drug Interactions With Ezetimibe/Simvastatin

Nefazodone
Taking ezetimibe/simvastatin and nefazodone is not recommended, as your body may metabolize the medicines differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Ranolazine
Combining ranolazine with ezetimibe/simvastatin may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of ezetimibe/simvastatin should not exceed 10/20 mg daily.
  
Verapamil
Combining verapamil and ezetimibe/simvastatin may cause your body to metabolize the drugs differently than intended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your ezetimibe/simvastatin dosage should not exceed 10/10 mg.
 
Warfarin
Ezetimibe/simvastatin may increase the risk of bleeding due to warfarin. When starting or stopping ezetimibe/simvastatin therapy and/or changing the dosage, your healthcare provider may choose to monitor your INR and prothrombin time more closely and make any necessary adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting.
 

Ezetimibe/Simvastatin Drug Interactions: Final Thoughts

Several drugs can interact with ezetimibe/simvastatin, and it is possible that not all interactions were discussed in this article. Therefore, you should talk with your doctor about specific drug interactions with ezetimibe/simvastatin that may apply to you.
 
Also, because some of these medicines can increase the risk of serious muscle problems, if you have any unexplained muscle pain or weakness (especially with a fever or if you feel ill), contact your healthcare provider immediately.
 
 
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Ezetimibe and Simvastatin Drug Information

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