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Drug Interactions With Ezetimibe/Simvastatin

Certain Antibiotics and Antifungals
Some antifungals and antibiotics can significantly increase the level of ezetimibe/simvastatin in your blood, increasing your risk for side effects, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. Unless your healthcare provider feels that the benefits outweigh the risks, these medicines should not be taken together. Your healthcare provider may recommend that you stop taking ezetimibe/simvastatin temporarily while your bacterial or fungal infection is being treated. In general, taking ezetimibe/simvastatin with erythromycin, telithromycin, or clarithromycin is not recommended at all.
 
Danazol
Combining danazol and ezetimibe/simvastatin is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Digoxin
Taking digoxin with ezetimibe/simvastatin appears to slightly increase the levels of digoxin in the blood. When starting ezetimibe/simvastatin or increasing your dosage, your healthcare provider may choose to monitor you more closely.
 
Diltiazem
Combining diltiazem with ezetimibe/simvastatin may increase the risk of serious muscle problems, such as myopathy or rhabdomyolysis. If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of ezetimibe/simvastatin should not exceed 10/10 mg once daily.
  
Fibrates
If you are taking ezetimibe/simvastatin and a fibrate, you may have an increased risk for serious reactions, including serious muscle problems like myopathy or rhabdomyolysis. Gallbladder problems could also occur. At this time, gemfibrozil and ezetimibe/simvastatin should not be combined. The other fibrates may be used with ezetimibe/simvastatin, but only with great caution.
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Ezetimibe and Simvastatin Drug Information

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