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Drug Interactions With Ezetimibe/Simvastatin

More Information on Interactions With Ezetimibe/Simvastatin

The following sections explain in detail how certain drugs can interact negatively with ezetimibe/simvastatin.
 
Amiodarone
Taking amiodarone and ezetimibe/simvastatin together may increase the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are taking these medicines, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your ezetimibe/simvastatin dosage should not exceed 10/20 mg once daily.
 
Amlodipine
Combining amlodipine with simvastatin may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of ezetimibe/simvastatin should not exceed 10/20 mg once daily.
 
Cobicistat
The risk of serious side effects (including myopathy or rhabdomyolysis) is increased by combining ezetimibe/simvastatin with cobicistat-containing medications, such as Stribild. In general, these medications should not be taken together.
 
Cyclosporine
Taking cyclosporine and simvastatin together is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
  
Bile Acid Sequestrants
Bile acid sequestrants can bind to ezetimibe/simvastatin in the digestive tract, preventing it from being absorbed into the bloodstream. To avoid this interaction, be sure to take ezetimibe/simvastatin at least two hours before or four hours after a bile acid sequestrant.
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Ezetimibe and Simvastatin Drug Information

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