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Drug Interactions With Etoposide

Mifepristone
Mifepristone may increase the level of etoposide in your bloodstream, which could increase your risk for etoposide side effects. This interaction is more likely to occur when mifepristone is taken on a regular basis, as opposed to one-time mifepristone doses that are used to end an early pregnancy.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove etoposide from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Taking etoposide with a Pgp inducer causes etoposide to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take etoposide with a Pgp inducer.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove etoposide from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking etoposide with a Pgp inhibitor causes etoposide to be removed more slowly, increasing the amount of etoposide in your blood and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take etoposide with a Pgp inhibitor.
 
Pimozide
Etoposide may increase blood levels of pimozide, which could increase your risk for pimozide side effects. Talk to your healthcare provider before using these medicines together.
 
Roflumilast
Combining roflumilast with etoposide could make you more susceptible to infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
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Etoposide Drug Information

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