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Drug Interactions With Etoposide

Cyclosporine
Cyclosporine can cause a significant increase in blood levels of etoposide, increasing your risk for potentially serious etoposide side effects. If you use these medicines together, your healthcare provider may choose to give you a lower etoposide dose.
 
CYP 3A4 Inducer Medications
The liver breaks down etoposide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining etoposide with one of these drugs may decrease the level of etoposide in your bloodstream, potentially making it less effective. Your healthcare provider may recommend you stop taking certain CYP 3A4 inducers before beginning etoposide treatment.
 
CYP 3A4 Inhibitor Medications
The liver breaks down etoposide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining etoposide with one of these drugs may increase the level of etoposide in your bloodstream, increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Echinacea
Echinacea could make etoposide less effective. Do not take echinacea during etoposide treatment unless recommended by your healthcare provider.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. Because you are more prone to infections, you could become infected with the virus or bacteria used to make a live vaccine during etoposide treatment. Also, live vaccines may be less effective in people using etoposide. In general, people using etoposide should not receive live vaccines. Talk to your healthcare provider before receiving a vaccination during etoposide treatment.
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Etoposide Drug Information

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