Drug Interactions With Dronedarone

There are a number of medications that may interfere with dronedarone. For example, if certain diuretics, beta blockers, or calcium channel blockers are taken together with the arrhythmia drug, you may increase your risk for developing serious problems such as a slow heart rate. In order to help prevent potentially dangerous dronedarone interactions, tell your healthcare provider about all other medications you are taking.

An Overview of Dronedarone Interactions

Dronedarone (Multaq®) can potentially interact with many other medications. Some of these medicines that may lead to drug interactions with dronedarone include (but are not limited to):
 

 

 

 

 

  • Certain diuretics, such as:

 

 

  • CYP 3A4 inducer medications, including (but not limited to):

 

 

  • CYP 3A4 inhibitor medications, including (but not limited to):

 

 

  • Digoxin (Digitek®, Lanoxin®)
  • Grapefruit juice
  • Medications that cause a certain heart rhythm change known as QT prolongation (see QT-Prolonging Medications)
  • Sirolimus (Rapamune®)
  • Some statin medications, such as:

 

 

  • Tacrolimus (Prograf®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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