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Drug Interactions With Dronedarone

CYP 3A4 Inhibitors
The liver metabolizes (breaks down) dronedarone using an enzyme known as CYP 3A4. Some medications (known as CYP 3A4 inhibitors) decrease the activity of this enzyme. Taking dronedarone with a strong CYP 3A4 inhibitor may drastically increase the level of dronedarone in the blood, increasing the risk of dangerous dronedarone side effects. Dronedarone should never be combined with a strong CYP 3A4 inhibitor.
 
Dabigatran
Dronedarone may increase the level of dabigatran in the body, which may lead to an increased risk of bleeding. Your healthcare provider may decide to monitor you for signs and symptoms of bleeding while taking dabigatran and dronedarone together.
  
Digoxin
Combining dronedarone with digoxin may increase the risk of side effects (of both medications) and may increase the level of digoxin in the blood. Because of the risk of these problems, your healthcare provider should carefully evaluate whether you truly need to be on both medications. If you must take both, it is recommended that your healthcare provider reduce your digoxin dosage by half and carefully monitor your digoxin blood levels.
 
Grapefruit Juice
Besides medications, grapefruit juice may also interact with dronedarone. It may significantly increase absorption of dronedarone from the digestive tract (increasing the risk of side effects). Do not drink grapefruit juice while taking dronedarone.
 
QT-Prolonging Medications
Dronedarone can cause a dangerous change in the heart rhythm known as QT prolongation. To help decrease the risk of this problem, dronedarone should never be combined with other medications that have this effect. Many different types of medications may have this effect (see QT-Prolonging Medications for a list of such medications).
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Dronedarone Drug Information

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